Figure 1.

Structural location of HCM mutations. A, structural model of the catalytic domain of β-MyHC (based on Protein Data Bank code 4P7H). The heavy chain is shown as a ribbon diagram with the major subdomains and HCM mutations color-coded. The mutations sites are shown in space filling form in individual colors. The same colors are used throughout the figures and tables. Color code: red, H251N; green, D382Y; light blue, P710R; purple, V763M; pink, R719W; yellow, R723G; maroon, G741R. The lever arm and the essential light chain (ELC) are shown in two different shades of green on the left. B, alignment of conserved MYH7 residues where mutations discussed throughout this study can be found.