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. 2019 Oct 3;294(46):17451–17462. doi: 10.1074/jbc.RA119.010563

Figure 7.

Figure 7.

Economy of force generation and velocity for HCM mutations. Top, ATP usage per second per pN of force while generating 5 pN of force at [A] = 3Kapp. Bottom, ATP used per second at maximum shortening velocity (zero load). Because ATPase and DR have the same dependence on [A], this calculation is the same at all actin concentrations except very low values where the motor cannot maintain constant velocity.