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. 2019 Nov 15;10:2593. doi: 10.3389/fimmu.2019.02593

Figure 2.

Figure 2

Reduced naive T-cell numbers in PAD patients. (A) Absolute numbers of total T cells, γδ T cells, CD4 T cells, and CD8 T cells. Horizontal dotted lines represent the 5th and 95th percentiles as calculated in healthy controls. Relative and absolute numbers of (B) CD4 T-cell subsets and (C) CD8 T-cell subsets. Naive (Tn; CCR7+CD45RO−), central memory (Tcm; CCR7+CD45RO+), effector memory (TemRO; CCR7−CD45RO−), and effector memory CD45RA revertant (TemRA; CCR7−CD45RO−). For gating strategy and population definitions, see Supplementary Figure 3 and Supplementary Table 3. PAD, predominantly antibody deficiency; NIC, non-infectious complications. Statistics were performed with the Kruskal–Wallis test, followed by Mann–Whitney tests for pairwise comparisons. *p < 0.5, **p < 0.01, ***p < 0.001, and ****p < 0.0001.