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. 2019 Nov 15;10:2593. doi: 10.3389/fimmu.2019.02593

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Copyright © 2019 Edwards, Bosco, Aui, Stirling, Cameron, Chatelier, Hore-Lacy, O'Hehir and van Zelm.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Reduced Treg and helper T-cell numbers in PAD patients with non-infectious complications. (A) Total Treg, naive Treg, memory Treg, and CD4 Tfr cells. (B) Th17 and Th17.1 cells. (C) Total Tfh and Tfh17 cells. All numbers represent cells per microliter of blood. For gating strategy and population definitions, see Supplementary Figure 4 and Supplementary Table 3. PAD, predominantly antibody deficiency; NIC, non-infectious complications. Statistics were performed with the Kruskal–Wallis test, followed by Mann–Whitney tests for pairwise comparisons. *p < 0.5, **p < 0.01, ***p < 0.001, and ****p < 0.0001.