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Comparison of Nell-1 and BMP-2 in Bone Regeneration.
| Nell-1 | BMP-2 | |
|---|---|---|
| Osteogenesis | Promote | Promote |
| Chondrogenesis | Promote | Promote |
| Adipogenesis | Inhibit | Promote |
| Inflammation | Inhibit | Promote |
| Mesenchymal stem cell migration | Promote | — |
| Endothelial cell migration | Promote | Promote |
| Angiogenesis | Promote | Promote |
| Tumorigenesis | Unclear | Promote |
| Ectopic bone formation | No | Yes |
| Osteoclast activation | Inhibit | Promote |
| Chemotaxis | — | Promote |
