Table 2.
Summary of included studies.
Study | Setting | Study design | Sample size | Subjects | Trial period | End-points | Method or intervention | Outcomes |
---|---|---|---|---|---|---|---|---|
The effect of calcium supplementation on blood pressure in non-pregnant women with previous pre-eclampsia: an exploratory, randomized placebo-controlled study (15) |
Sub-study of WHO Calcium and Pre-eclampsia (CAP) Trial | RCT |
N = 836 randomized N = 367 first visit N = 217 History severe PE |
Non-pregnant women who had PE or eclampsia in their immediately previous pregnancy. |
12 or 24 weeks after randomization | Blood pressure (systolic and diastolic) |
500 mg/day Calcium or placebo |
Overall trend toward decreased BP in supplemented group but NS (reduction of 1–2.5 mmHg) Statistically significant reduction in diastolic BP of severe PE group |
Randomized Trial to Reduce Cardiovascular Risk in Women with Recent Preeclampsia (16) |
Standalone controlled intervention trial. | RCT | N = 151 (assessed for eligibility n = 1,493) | Women with PE affected pregnancy, within 5-years of index pregnancy | 9 months | Healthy diet and increase activity, change in physical in/activity, DASH diet, knowledge of risk. Weight/BP |
Online intervention (educational modules, community forum, life-style coach communication) Control: Links to standard CVD risk information |
High rate of access of intervention information [84% of participants accessed a minimum of 1 online module) and access to coach [89% had 3 calls with a coach) Self-reported increased knowledge of CVD risk factors (p = 0.01 corrected), self-efficacy for healthy eating (p = 0.03), less physical inactivity (p = 0.0006). No difference in adherence to DASH diet, sense of control of risk factors, self-efficacy for physical activity or reported physical activity. No difference in secondary outcomes (weight, blood pressure) |
RCT, Randomized Controlled Trial; WHO, World Health Organization; NS, Not significant; PE, Preeclampsia; DASH, Dietary Approaches to Stop Hypertension; CVD, Cardiovascular disease.