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. 2019 Nov 15;6:160. doi: 10.3389/fcvm.2019.00160

Table 2.

Summary of included studies.

Study Setting Study design Sample size Subjects Trial period End-points Method or intervention Outcomes
The effect of calcium supplementation on blood pressure in non-pregnant women
with previous pre-eclampsia: an exploratory, randomized placebo-controlled study
(15)
Sub-study of WHO Calcium and Pre-eclampsia (CAP) Trial RCT N = 836 randomized
N = 367 first visit
N = 217 History severe PE
Non-pregnant women who had PE or eclampsia
in their immediately previous pregnancy.
12 or 24 weeks after randomization Blood pressure (systolic
and diastolic)
500 mg/day Calcium
or placebo
Overall trend toward decreased BP in supplemented group but NS (reduction of 1–2.5 mmHg)
Statistically significant reduction in diastolic BP of severe PE group
Randomized Trial to Reduce Cardiovascular Risk in Women with Recent Preeclampsia
(16)
Standalone controlled intervention trial. RCT N = 151 (assessed for eligibility n = 1,493) Women with PE affected pregnancy, within 5-years of index pregnancy 9 months Healthy diet and increase activity, change in physical in/activity, DASH diet, knowledge of risk.
Weight/BP
Online intervention (educational modules, community forum, life-style coach communication)
Control: Links to standard CVD risk information
High rate of access of intervention information [84% of participants accessed a minimum of 1 online module) and access to coach [89% had 3 calls with a coach)
Self-reported increased knowledge of CVD risk factors (p = 0.01 corrected), self-efficacy for healthy eating (p = 0.03), less physical inactivity (p = 0.0006).
No difference in adherence to DASH diet, sense of control of risk factors, self-efficacy for physical activity or reported physical activity.
No difference in secondary outcomes (weight, blood pressure)

RCT, Randomized Controlled Trial; WHO, World Health Organization; NS, Not significant; PE, Preeclampsia; DASH, Dietary Approaches to Stop Hypertension; CVD, Cardiovascular disease.