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. 2019 Nov 15;10:2688. doi: 10.3389/fimmu.2019.02688

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Copyright © 2019 Ali, Komal, Almutairi and Lee.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NK cell-derived IL-10 regulates T cell activation during sustained MCMV infection. PKO-Il10^fl/fl (Cre−) and PKO-NKp46-Cre-Il10^fl/fl (Cre+) mice were either uninfected or given 5,000 PFU MCMV i.p. (A,B) NK cells, CD4 T cells, and CD8 T cells from the spleens and livers of PKO-Il10^fl/fl (n = 4) and PKO-NKp46-Cre-Il10^fl/fl (n = 4) mice at day 5 post-infection were stained for IFNγ production (three experiments). Data represent mean + SD. ns, non-significant; *p < 0.05; **p < 0.01; ***p < 0.001.