Table 2.

Cycle characteristics and pregnancy outcomes of older patients with diminished ovarian reserve (POSEIDIN group 4) treated with or without DHEA.

Parameters	DHEA	Non-DHEA	p-value
	(n = 159)	(n = 138)
Stimulation duration (days)	10.7 ± 2.3	10.3 ± 2.4	0.139
Types of gonadotropins			0.350
rFSH only	6.9%	7.2%
rFSH/rLH	61.6%	68.8%
HMG	31.4%	23.9%
Combination with corifollitropin alfa (%)	21.4%	21.7%	0.941
Gonadotropin dosage (IU)
With corifollitropin alfa	1727.6 ± 515.9	1440.0 ± 997.5	0.051
Without corifollitropin alfa	2839.0 ± 834.6	2929.3 ± 834.6	0.456
Oocyte trigger (%)			0.102
Dual trigger	81.1	73.2
hCG trigger	18.9	26.8
No. of retrieved oocytes (n)	3.1 ± 2.8	1.9 ± 1.8	<0.001
Follicular oocyte index (%)	58.8 ± 36.9	43.5 ± 35.2	<0.001
No. of retrieved oocytes > 3 (%)	33.3	19.6	0.008
No. of metaphase II oocytes (n)	2.6 ± 2.1	1.7 ± 1.5	<0.001
No. of fertilized oocytes (n)	2.1 ± 2.0	1.4 ± 1.5	0.001
No. of Day 3 embryos (n)	1.9 ± 1.9	1.3 ± 1.4	0.001
Day 3 embryos rate (%)	94.0 ± 18.0	94.2 ± 17.2	0.935
No. of top-quality Day 3 embryos (n)	0.8 ± 1.3	0.4 ± 0.7	0.001
Day of embryo transfer			0.011
Day 3	86.2%	94.9%
Day 5	13.8%	5.1%
No. of embryo transfer (n)	1.1 ± 0.9	0.8 ± 0.6	<0.001
No. of embryo transfer > 1 (%)*	36.3%	10.9%	<0.001
Clinical pregnancy rate (%) / per cycle	17.6	11.6	0.146
Cumulative pregnancy rate (%)	29.5	14.8	0.011
Live birth rate (%) / per cycle	11.9	9.4	0.483
Cumulative live birth rate (%)	20.0	12.0	0.120
Cancellation rate (%)	18.9%	29.7%	0.029

Data are presented as mean ± standard deviation or %.

DHEA, dehydroepiandrosterone; rFSH, recombinant follicle stimulating hormone; rLH, recombinant luteinizing hormone; HMG, human menopausal gonadotropins; hCG, human chorionic gonadotrophin.

^*only transferable cycles were calculated.