Table 4.
Subgroup analyses (categorized relative to the age of 40) of older patients with diminished ovarian reserve (POSEIDIN group 4) treated with or without DHEA.
| ≤40 (35~40) y/o | >40 (41~45) y/o | |||||
|---|---|---|---|---|---|---|
| Parameters | DHEA | Non-DHEA | p-value | DHEA | Non-DHEA | p-value |
| (n = 97) | (n = 77) | (n = 62) | (n = 61) | |||
| Age (years) | 38.3 ± 1.7 | 38.0 ± 1.6 | 0.339 | 42.3 ± 1.3 | 42.9 ± 1.3 | 0.017 |
| Body mass index (kg/m2) | 22.4 ± 3.6 | 23.0 ± 4.0 | 0.371 | 22.0 ± 2.0 | 23.1 ± 3.3 | 0.024 |
| Basal FSH (IU/l) | 7.3 ± 5.3 | 6.5 ± 4.1 | 0.287 | 7.2 ± 3.1 | 6.2 ± 4.1 | 0.131 |
| Antral follicle counts (n) | 4.7 ± 2.2 | 4.5 ± 2.3 | 0.532 | 4.2 ± 2.6 | 3.9 ± 2.1 | 0.588 |
| Anti-Müllerian hormone (ng/ml) | 0.5 ± 0.3 | 0.7 ± 0.3 | < 0.001 | 0.6 ± 0.4 | 0.6 ± 0.3 | 0.629 |
| No. of oocytes retrieved (n) | 3.1 ± 2.5 | 2.1 ± 1.8 | 0.002 | 3.0 ± 3.1 | 1.8 ± 1.7 | 0.010 |
| No. of metaphase II oocytes (n) | 1.6 ± 1.3 | 1.2 ± 1.3 | 0.043 | 1.6 ± 1.8 | 0.9 ± 1.1 | 0.009 |
| Maturation rate (%) | 59.2 ± 30.9 | 60.2 ± 35.5 | 0.863 | 60.7 ± 32.5 | 54.9 ± 36.1 | 0.422 |
| No. of fertilized oocytes (n) | 2.1 ± 1.9 | 1.5 ± 1.5 | 0.019 | 2.0 ± 2.2 | 1.3 ± 1.3 | 0.024 |
| Fertilization rate (%) | 68.5 ± 30.4 | 71.5 ± 34.3 | 0.581 | 74.4 ± 30.1 | 78.0 ± 28.6 | 0.567 |
| No. of Day 3 embryos (n) | 2.0 ± 1.8 | 1.4 ± 1.5 | 0.011 | 1.8 ± 2.1 | 1.2 ± 1.2 | 0.040 |
| No. of top-quality Day 3 embryos (n) | 0.8 ± 1.3 | 0.5 ± 0.8 | 0.028 | 0.7 ± 1.3 | 0.3 ± 0.6 | 0.027 |
| Clinical pregnancy rate (%)/per cycle | 18.6 | 14.3 | 0.453 | 16.1 | 8.2 | 0.179 |
| Cumulative pregnancy rate (%) | 28.6 | 18.0 | 0.166 | 31.2 | 10.6 | 0.022 |
| Live birth rate (%)/per cycle | 13.4 | 11.7 | 0.735 | 9.7 | 6.6 | 0.527 |
| Cumulative live birth rate (%) | 20.6 | 14.8 | 0.391 | 18.8 | 8.5 | 0.179 |
Data are presented as mean ± standard deviation or %. FSH, follicle stimulation hormone.