Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Nov 21;21:123. doi: 10.1186/s13058-019-1216-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 1 — WDR5 controls tumorigenesis in breast cancer. a MCF10DCIS cell line was infected to silence WDR5 (shWDR5) or a neutral control (shLuc) and inoculated in vivo in immunocompromised mice. When tumors of control group reached maximum volume expected, all the mice were sacrificed to compare effect on tumor growth. Dot plots represent tumor volume in shWDR5 or shLuc MCF10DCIS (n = 9 per group; mean ± SD—cm³). Statistical significance was determined using an unpaired Student t test (***P < 0.001). b In vitro relative proliferation values of shWDR5 in MCF10DCIS cells are reported with respect to control (shLuc). Statistical significance on n = 3 experiments was determined using an unpaired Student t test (***P < 0.001). c Percentage of survival of mice belonging to control or shWDR5 groups was calculated. Mice were sacrificed when each tumor reached maximum volume expected. Differences among groups were calculated by using Log-rank test (n = 5 per group; P = 0.0052). d Six MBC PDXs were infected to target control (shLuc) and shWDR5. Transduced cells were transplanted in NSG mice. Dot plots represent volume (mean ± SD—cm³) of three to four tumors per group. Statistical significances were calculated by applying an unpaired Student t test (**P < 0.01; ***P < 0.001)