Table IV.
Variations in mtDNA-encoded complex I genes identified only in patients with multiple sclerosis.
| Gene | Nucleotide change | No. of nucleotide changes | Amino acid change |
|---|---|---|---|
| ND1 | m.3513C>T | 1 | - |
| m.3533C>T | 1 | - | |
| m.3594C>T | 5 | - | |
| m.4059C>T | 1 | - | |
| m.4312C>T | 3 | - | |
| m.3944A>G | 1 | - | |
| m.3720A>G | 3 | - | |
| m.3948A>G | 1 | - | |
| m.3865A>G | 3 | - | |
| m.3866T>C | 1 | - | |
| m.3944T>C | 2 | - | |
| ND3 | m.10343C >T | 1 | - |
| m.10355G>A | 1 | - | |
| NDL4 | m.10499A>G | 4 | - |
| m.10586G>C | 1 | - | |
| m.10664C>T | 2 | - | |
| ND4 | m.10819A>G | 2 | - |
| m.10895A>G | 2 | - | |
| m.11002A>G | 1 | - | |
| m.11172A>G | 4 | - | |
| m.11337A>G | 2 | - | |
| m.11380A>G | 1 | - | |
| m.11143C>T | 2 | - | |
| m.11150G>A | 1 | A131T | |
| m.11377G>A | 4 | - | |
| m.11440G>A | 4 | - | |
| m.11518G>T | 1 | - | |
| m.11519A>C | 1 | T254P | |
| m.11523A>C | 1 | K255T | |
| m.11527C>T | 1 | H256L | |
| ND5 | m.12570A>G | 4 | - |
| m.12615A>G | 1 | - | |
| m.12753A>G | 1 | - | |
| m.13104A>G | 1 | - | |
| m.14007A>G | 2 | - | |
| m.14070A>G | 1 | - | |
| m.12843T>C | 1 | - | |
| m.12879T>C | 1 | - | |
| m.13020T>C | 3 | - | |
| m.13174T>C | 2 | - | |
| m.13734T>C | 3 | - | |
| m.13116C>T | 2 | - | |
| m.13695C>T | 1 | - | |
| m.13317G>A | 1 | - | |
| m.13590G>A | 2 | - | |
| m.13813G>A | 4 | - | |
| m.14100C>T | 1 | - | |
| ND6 | m.14155C>T | 1 | - |
| m.14305G>A | 1 | - | |
| m.14308T>C | 2 | - | |
| m.13116C>T | 2 | - | |
| m.13695C>T | 1 | - | |
| m.13317G >A | 1 | - | |
| m.13590G >A | 2 | - | |
| m.13813G >A | 4 | - | |
| m.14100C>T | 1 | - | |
| m.14155C>T | 2 | - | |
| m.14305G>A | 1 | - | |
| m.14308T>C | 1 | - |