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Missense mutations in ND4 gene identified in patients with multiple sclerosis.
| Gene | Patient no. | PDB File | Chain ID | Nucleotide change | Amino acid change | Predicted ΔΔG | Outcome |
|---|---|---|---|---|---|---|---|
| ND4 | 48 | ND4.pdb | r | m.11150G>A | A131T | -2.05 | Reduced stability |
| ND4 | 44 | ND4.pdb | r | m.11519A>C | T254P | -1.54 | Reduced stability |
| ND4 | 44 | ND4.pdb | r | m.11523A>C | K255T | -0.95 | Reduced stability |
| ND4 | 44 | ND4.pdb | r | m.11527C>T | H256L | 0.99 | Neutral |
