Table VI.

Characteristics of patients with RRMS with missense mutations in the ND4 gene.

Characteristics	Patient no. 44	Patient no. 48
Sex	Female	Female
Age (years)	31	25
Disease duration (years since diagnosis)	6	4
Number of relapses per year	1	1
Main neurological dysfunction	Blurry vision, pain on ocular movement, sensory ataxia, weakness, numbness, imbalance	Imbalance, incoordination of movement, weakness on lower limbs, numbness, imbalance
EDSS	3.7	2.4
MRI and LP findings	Mainly paraventricular and cervical hyperintensity representing demyelination lesions	Mainly paraventricular and cervical hyperintensity representing demyelination lesions
Previous medication	Rebif	Avonex
Current medication	Gilenya	Avonex

RRMS, relapse-remitting multiple sclerosis; EDSS, expanded disability status scale; MRI, magnetic resonance imaging; LP, lumbar puncture.