Fig. 3.

No change in pericyte coverage in CADASIL patients. Immunostaining for capillary endothelium (glut-1; a-b) and for pericytes (PDGFR-β; c-d) on serial sections from normal appearing white matter (NAWM) in a control brain (a, c) and a “pure” white matter lesion (WML) in a CADASIL patient brain (b, d). Capillary area is quantified in (e), pericyte area is quantified in (f), and the ratio of pericyte stained area to capillary stained area is quantified in (g). Mean ± SEM; **: p < 0.01; one-way ANOVA with Tukey’s post-hoc tests; n = 6 (controls), 7 (patients). Scale bar: 50 μm