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. 2019 Nov 21;7:187. doi: 10.1186/s40478-019-0844-x

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — No blood brain barrier (BBB) leakage in the white matter of CADASIL mice. a-c Immunofluorescent images showing fibrinogen (green) and capillaries (glut-1; white) in the anterior corpus callosum (CC) of Col4a1^+/G498V (a), TgNotch3^WT (b), and TgNotch3^R169C (c) mice. Fibrinogen staining is quantified in both the anterior and posterior CC (d). e-g Fluorescent images showing injected cadaverine (red) and capillaries (glut-1; white) in the anterior CC of Col4a1^+/G498V (e), TgNotch3^WT (f), and TgNotch3^R169C (g) mice. Cadaverine leakage is quantified in both the anterior and posterior CC (h). Mean ± SEM; ****: p < 0.0001; two-way ANOVA with Tukey’s post-hoc tests; n for each group shown on graphs. Scale bar: 25 μm