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. 2019 Nov 15;9:1201. doi: 10.3389/fonc.2019.01201

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Copyright © 2019 Han, Wei, Zhang, Jiang, Fan, Huang, Xie, Zhang, Miao, Butler, Coleman, Vaughan, Wang, Chen, Liu and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Blocking CPT1A/CPT2 synergizes radiation in eliminating clonogenic RBCs cells. Representative images (A) of colonies generated with 1 × 10³ MCF7, MCF7/C6, MCF7/C6 CPT1A KO, and MCF7/C6 CPT2 KO cells treated with or without 5 Gy IR, 40 μM ETX, or combined. All colonies were fixed at day 14 and quantitated (B). (C,D) Same as (A,B) except that MDA231, MDA231/C4 CPT1A KO, MDA231/C4 CPT2 KO, and MDA231/C4 cells were tested. In all experiments, n = 3; Error bars in (B,D) represent mean ± SD; significance was determined by one-way ANOVA test, ^**p < 0.01, ^***p < 0.001.