Table 3.
Rare variant burden analysis for nonsynonymous variants within all types of HPV for the cervicitis, LSIL and HSIL groups
| N Controls | N LSIL | N HSIL | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Viral | Number | with | % of | Number | with | % of | Number | with | % of | |
| Gene | IF | Variants | Controls | LSIL | Variants | Controls | HSIL | Variants | Controls | P Value |
| E6 | 86 | 55 | 64.0 | 63 | 32 | 50.8 | 84 | 45 | 53.6 | 0.215 |
| E7 | 73 | 53 | 72.6 | 58 | 31 | 53.4 | 81 | 32 | 39.5 | 3.17 × 10–4* |
| Total | 159 | 108 | 67.9 | 121 | 63 | 52.1 | 165 | 77 | 46.7 | 3.83 × 10–4* |
HPV Human papillomavirus; IF cervicitis; LSIL low-grade squamous intraepithelial lesion; HSIL high-grade squamous intraepithelial lesion;*P values remain significant after Bonferroni adjustment for multiple tests