Table 1.
Demographic and baseline characteristics of ICU patients with Stenotrophomonas maltophilia hospital-acquired pneumonia
| Variables | Total N = 282 |
|---|---|
| Gender, male | 197 (69.9) |
| Age, years | 65 [56–74] |
| BMI (kg m− 2) | 25.3 [22–28.8] |
| Reason for ICU admission | |
| Medical condition | 167 (59.2) |
| Scheduled surgery | 32 (11.3) |
| Emergent surgery | 83 (29.4) |
| Postoperative period of cardiac surgery | 60 (21.3) |
| Previous carriage of S. maltophilia | 13 (4.6) |
| Pulmonary comorbidities | |
| Chronic obstructive pulmonary disease | 51 (18.1) |
| Chronic respiratory insufficiency | 30 (10.6) |
| Cystic fibrosis | 2 (0.7) |
| Other comorbidities | |
| Hypertension | 147 (52.1) |
| Congestive heart failure | 66 (23.4) |
| Dialysis-dependent chronic kidney disease | 8 (2.8) |
| Liver cirrhosis | 22 (7.8) |
| Insulin-requiring diabetes | 31 (11) |
| Severe neurologic disability | 30 (10.6) |
| Habits | |
| Active smoking | 86 (30.5) |
| Chronic alcohol abuse | 47 (16.7) |
| Drug abuse | 8 (2.8) |
| Immune comprise conditions (n, %) | |
| Neutropenia | 1 (0.3) |
| HIV and/or CD4 count < 50/mm3 | 1 (0.3) |
| Recent or ongoing chemotherapy | 11 (3.9) |
| Hematologic malignancy | 16 (5.7) |
| Solid tumor being actively treated | 20 (7.1) |
| Solid tumor in remission | 22 (7.8) |
| Immunosuppressive therapy or corticosteroids use > 0.5 mg/kg > 30 days | 34 (12) |
| Innate or acquired immune deficiency | 1 (0.3) |
| Severity scores | |
| SOFA score at admission | 8 [5–11] |
| SAPS II at 24 h | 47 [36–63] |
| Ventilator-associated pneumonia | 228 (80.8) |
| Duration of ventilation before S. maltophilia HAP, days | 11 [5–18] |
| ICU length of stay, days | 32 [19–58] |
| Hospital length of stay, days | 54 [30–94] |
| Number of days between hospital admission and S. maltophilia HAP | 16 [8–27] |
| Number of days between ICU admission and S. maltophilia HAP | 11 [5–19] |
| Mortality | 140 (49.7) |
| Mortality directly attributable to S. maltophilia | 34 (24.3) |
Data are expressed as number and percentage or median [interquartile range] as appropriate
BMI body mass index, HAP hospital-acquired pneumonia, HIV human immunodeficiency virus, ICU intensive care unit, IQR interquartile range, SAPS Simplified Acute Physiology Score, SD standard deviation, SOFA Sequential Organ Failure Assessment, S. maltophilia Stenotrophomonas maltophilia