Table 4.
Variables associated with the time to in-hospital death
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR [95%CI] | p value | HR [95%CI] | p value | |
| Age | 1.025 [1.012; 1.038] | 0.0001 | 1.02 [1.01; 1.04] | 0.001 |
| SAPS II | 1.009 [1.001; 1.018] | 0.036 | ||
| Mechanical ventilation at diagnosis | 1.692 [0.83; 3.46] | 0.151 | ||
| VAP | 0.748 [0.49; 1.14] | 0.178 | ||
| Duration of MV before the diagnosis | 0.997 [0.988; 1.006] | 0.462 | ||
| SOFA score at diagnosis | 1.099 [1.057; 1.142] | < 0.0001 | 1.1 [1.06; 1.15] | < 0.001 |
| Bacteremia | 0.814 [0.41; 1.60] | 0.551 | ||
| Monomicrobial pneumonia | 1.368 [0.98; 1.91] | 0.066 | ||
| Co-infection with Pseudomonas aeruginosa | 0.843 [0.53; 1.33] | 0.464 | ||
| Time elapsed between pulmonary sample and effective antimicrobial therapy | 0.99 [0.97; 1.01] | 0.434 | ||
| < 24 h | 1 | |||
| 24–48 h | 1.22 [0.74; 2] | 0.429 | ||
| > 48 h | 1.34 [0.85; 2.12] | 0.204 | ||
| Empirical antibiotic therapy | 1.019 [0.73; 1.43] | 0.914 | ||
| Subsequent septic shock | 3.070 [1.9; 5.0] | < 0.0001 | ||
| Empirical antibiotic therapy effective against S. maltophilia | 0.839 [0.52; 1.35] | 0.4705 | ||
| Effective combination antimicrobial therapy | 1.27 [0.88; 1.83] | 0.204 | ||
| Duration of effective antimicrobial therapy against S. maltophilia | 1.03 [0.98;1.07] | 0.243 | ||
| < 7 days | 1 | |||
| 7–14 days | 1.06 [0.6; 1.86] | 0.842 | ||
| > 14 days | 0.88 [0.45; 1.71] | 0.706 | ||
| Duration of effective combination therapy against S. maltophilia | 0.99 [0.96; 1.03] | 0.679 | ||
| < 7 days | 1 | |||
| 7–14 days | 0.82 [0.52; 1.29] | 0.393 | ||
| > 14 days | 0.71 [0.39; 1.29] | 0.262 | ||
SAPS Simplified Acute Physiology Score, VAP ventilator-associated pneumonia, MV mechanical ventilation, HR hazard ratio, S. maltophilia Stenotrophomonas maltophilia, SOFA Sequential Organ Failure Assessment