Fig. 5.
Associations between variably methylated regions (VMRs) and reproduction traits. a The -log(P) values of associations of VMRs with four types of complex traits. Red dot line indicates the significant P value after Bonferroni correction (P < 2.89 × 10-6; 0.05/17323). b Manhattan plots of five traits with significant/suggestively significant VMRs. Red dots indicated the significant VMRs (P < 2.89 × 10−6; 0.05/17323). Green dots indicated the suggestive significant VMRs (P < 5.77 × 10−5; 1/17323). CCR: cow conception rate; DPR: daughter pregnancy rate; GL: gestation length; ST_PL: standard length of productive life. c Correlation between predicted transmitting ability (PTA) values of DPR and methylation levels of VMR within the ZFP36L1 gene. d Correlation between PTA values of DPR and methylation levels of VMR located downstream of CRISP2 gene. e Expression levels (FPKM values) of four genes associated with significant VMRs across 91 bovine tissues