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. 2019 Nov 21;20:888. doi: 10.1186/s12864-019-6228-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — A trait-related variably methylated region (VMR) was associated with a SNP within 1 Mb distance. a UCSC browser of the VMR associated with CCR and DPR as well as the methylation QTL (meQTL) associated with the trait-related VMR (chr18: 57097832–57,097,893). Y axis indicates the –log10(P) from association test. b Association studies between the meQTL (rs109326022) and 35 bovine complex traits in 27, 214 Holstein bulls [44]. PL and SCE were the most significant traits associated with the meQTL. c Methylation levels of the trait-related VMR in three genotypes of rs109326022