Table 4.
Logistic regression model showing factors associated with clinically relevant fibrosis at baseline (N = 2419)
| APRI> 1.5 (clinically relevant fibrosis) at baseline | ||||||
|---|---|---|---|---|---|---|
| Univariate Analysis | Multivariable Analysis | |||||
| Variable | OR | 95% CI | Wald p | OR | 95% CI | Wald p |
| Hepatitis B | ||||||
| HBV negative | Reference | Reference | ||||
| HBV positive | 3.18 | 2.10–4.84 | < 0.0001 | 3.08 | 1.99–4.78 | < 0.001 |
| Hepatitis C | ||||||
| HCV negative | Reference | Reference | ||||
| HCV positive | 4.77 | 3.43–6.63 | < 0.0001 | 4.55 | 3.26–6.35 | < 0.001 |
| Baseline AIDS | ||||||
| No ADI ever | Reference | |||||
| None before/at FARVDT | 1.49 | 0.74–2.98 | 0.44 | – | ||
| ≥ 1 before/at FARVDT | 1.63 | 0.77–3.46 | ||||
| Race | ||||||
| White | Reference | |||||
| Black | 0.40 | 0.23–0.70 | ||||
| Indigenous | 1.13 | 0.61–2.09 | ||||
| Asian | 0.67 | 0.33–1.36 | 0.01 | – | ||
| Hispanic | 0.29 | 0.09–0.93 | ||||
| Other | 1.35 | 0.66–2.80 | ||||
| Unknown | 0.88 | 0.56–1.38 | ||||
| Birth sex | ||||||
| Female | Reference | |||||
| Male | 1.06 | 0.70–1.62 | 0.78 | – | ||
| Province | ||||||
| BC | Reference | |||||
| ON | 0.47 | 0.32–0.68 | < 0.0001 | – | ||
| QC | 0.44 | 0.26–0.72 | ||||
| Years on ARV | 1.02 | 0.98–1.06 | 0.37 | |||
| Age at first ARV | 1.02 | 1.01–1.04 | 0.003 | 1.02 | 1.00–1.04 | 0.01 |
| MSM | 0.63 | 0.46–0.88 | 0.006 | – | ||
| PWID | 3.47 | 2.49–4.82 | < 0.0001 | – | ||
| Baseline HIV viral load (Log10 copies/mL) | ||||||
| < 4 | Reference | Reference | ||||
| 4–5 | 1.68 | 0.91–3.08 | 0.004 | 1.49 | 0.80–2.77 | 0.21 |
| > 5 | 2.46 | 1.35–4.48 | 2.15 | 1.16–3.97 | 0.02 | |
| Baseline CD4 count (cells/mm3) | ||||||
| > 500 | Reference | |||||
| 350–499 | 1.60 | 0.70–3.70 | ||||
| 200–349 | 1.82 | 0.85–3.92 | 0.0007 | |||
| ≤ 100 | 2.76 | 1.32–5.77 | ||||
FARVDT first naïve ARV date, MSM Men who have Sex with Men, PWID People Who Infect Drugs, BC British Colombia, ON Ontario, QC Quebec
Variables considered in the multivariate model included: hepatitis B, hepatitis C, race, province, age at first ARV treatment, MSM, baseline HIV viral load, baseline CD4 count. Due to co-linearity with hepatitis C, PWID was not included in the final model