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. 2019 Nov 21;19:1137. doi: 10.1186/s12885-019-6347-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Immunohistochemistry in the primary tumor tissues for Nrf2. a (× 200): In the tumors with C/C genotype for rs6721961 SNP of the Nrf2, lower histological grade, some tumor cells showed weak reaction for anti-Nrf2 antibody (lower expression). b (× 200): In the tumors with C/A genotype, higher histological grade, much of the tumor cells showed moderate to strong brown staining (higher expression)