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. 2019 Nov 21;19:1137. doi: 10.1186/s12885-019-6347-0

Table 2.

Relationship between SNPs at rs6721961 and Nrf2 expression (n = 50)

C/C at rs6721961 (n = 30) C/A or A/A at rs6721961 (n = 20) p value
Mutation (+) of Nrf2 (n = 5) 0 5 0.0543
No mutation of Nrf2 (n = 45) 30 15
Low in Nrf2 (n = 26) High in Nrf2 (n = 24) p value
Mutation (+) of Nrf2 (n = 5) 0 5 0.0184
No mutation of Nrf2 (n = 45) 26 19
Low in Nrf2 (n = 26) High in Nrf2 (n = 24) p value
C/C at rs6721961 (n = 30) 22 8 0.0005
C/A or A/A at rs6721961 (n = 20) 4 16
Mutation (+) of Nrf2 (n = 5) No mutation of Nrf2 (n = 45) p value
Mutation (+) of Keap1 (n = 11) 2 9 0.3057
No mutation of Keap12 (n = 39) 3 36
C/C at rs6721961 (n = 30) C/A or A/A at rs6721961 (n = 20) p value
Mutation (+) of Keap1 (n = 11) 7 4 0.7804
No mutation of Keap12 (n = 39) 23 16
Low in Nrf2 (n = 26) High in Nrf2 (n = 24) p value
Mutation (+) of Keap1 (n = 11) 4 7 0.3057
No mutation of Keap12 (n = 39) 22 17