Table 3.

Relationship between molecules and treatment response in metastatic lesions (n = 50)

	CR/PR/SD > 12w* (n = 26)	SD < 12w/PD* (n = 24)	p value
Mutation of Nrf2
(+) (n = 5)	0	5	0.0142
(−) (n = 45)	26	19
SNPs at rs6721961
C/C (n = 30)	21	9	0.0018
C/A or A/A (n = 20)	5	15
Nrf2 expresion
Low (n = 26)	21	5	< 0.0001
High (n = 24)	5	19
Mutation of Keap1
(+) (n = 11)	6	5	0.8783
(−) (n = 39)	20	19

CR/PR/SD > 12w* Complete response, partial response, or stable disease for > 12 weeks

SD < 12w/PD* Stable disease for < 12 weeks or progressive disease