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. 2019 Nov 21;19:1137. doi: 10.1186/s12885-019-6347-0

Table 3.

Relationship between molecules and treatment response in metastatic lesions (n = 50)

CR/PR/SD > 12w* (n = 26) SD < 12w/PD* (n = 24) p value
Mutation of Nrf2
 (+) (n = 5) 0 5 0.0142
(−) (n = 45) 26 19
SNPs at rs6721961
 C/C (n = 30) 21 9 0.0018
 C/A or A/A (n = 20) 5 15
Nrf2 expresion
 Low (n = 26) 21 5 < 0.0001
 High (n = 24) 5 19
Mutation of Keap1
  (+) (n = 11) 6 5 0.8783
  (−) (n = 39) 20 19

CR/PR/SD > 12w* Complete response, partial response, or stable disease for > 12 weeks

SD < 12w/PD* Stable disease for < 12 weeks or progressive disease