Fig. 4.

Z_ADC map as a new MRI measurement to quantify the voxel-wise deviation from normal. a From ADC maps of normative neonates (left, upper part), we constructed the mean ADC (left) and standard deviation (stdev) of the ADC map (left, lower part). b Demonstration of Z_ADC maps in four neonates with HIE. The top image of each column is a representative axial ADC map through areas of injury. The color coding indicates the Z-score relative to the age matched normative atlas in a. This approach allows us to detect regions of decreased ADC, which have been associated with outcome, as well as explore the relevance of high ADC values, which occur with vasogenic edema