Fig. 5.

Probabilistic lesion frequency atlases to quantify key brain regions associated with treatment and outcome. a Lesion atlas in 141 patients; b lesions atlases in patients having not undergone therapeutic hypothermia (left) and having undergone therapeutic hypothermia (middle), and the brain regions that show significant decreases in lesion frequency with treatment (right); c lesion atlases in patients with (left) and without (middle) motor impairment at ~ 2 years, and the regions that were more often injured with this outcome. In the second row of a and first two columns in b and c, the color at a voxel denotes the frequency of lesions (i.e., percentage of patients in our cohort having lesions at this voxel), which is indexed by the color bar at the bottom of each panel. In the right column of b and c, the red color shows the voxels where the two sub-cohorts in the left and middle columns of each panel have significant differences in lesion occurrence. That is, in b, the red in the right column shows the regions where patients having received hypothermia have significantly lower frequencies of lesions than patients not undergoing hypothermia