Table 4.

A list features to be used for lesion-based outcome prediction

Categories	Details of features
I. Lesion anatomy	I.1. Mass center in standard neonatal atlas space I.2. Percentage of the whole-brain volume and the volume of each of the 61 auto-segmented brain structures being injured [76, 78, 122] I.3. Ratios of volumetric injury in the same brain structures between the left and right hemisphere I.4. Percentage and distribution of HIE lesions in 28 major fiber tracts as defined in the JHU atlas [123]
II. Lesion geometry	II.1. Lesion volume II.2. Maximum diameter along different orthogonal directions, maximum surface of lesion, lesion compactness, lesion spherecity, surface-to-volume ratio
III. Lesion heterogeneity	III.1. Histogram analysis (0, 25, 50, 75 and 100-percentile) of T1, T2, DWI, ADC, ZT1, ZT2, ZDWI, ZADC signal values within the lesion regions III.2. Skewness (asymmetry), kurtosis (flatness), uniformity and randomness (entropy and standard deviations) of T1, T2, DWI, ADC, ZT1, ZT2, ZDWI, ZADC signal values within the lesion regions
IV. Lesion texture	IV.1. gray-level co-occurrence matrix (GLCM) features and gray-level run-length matrix (GLRLM) of T1, T2, DWI, ADC, ZT1, ZT2, ZDWI, ZADC signal values within lesion regions IV.2. fractal analysis, Minkowski functionals, wavelet transform and Laplacian transforms of Gaussian-filtered images for the lesion regions