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. 2019 Nov 15;9:1215. doi: 10.3389/fonc.2019.01215

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Copyright © 2019 Vanhove, Graulus, Mesotten, Thomeer, Derveaux, Noben, Guedens and Adriaensens.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gluconeogenesis pathway in glucose deprived lung cancer cells. α-KG, α-ketoglutarate; ALDO, aldolase; ASCT2, alanine-serine-cysteine-transporter 2; DHAP, dihydroxyacetone phosphate; ENO, enolase; FBP, fructose bisphosphatase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; LDH, lactate dehydrogenase; MCT1, monocarboxylate transporter 1; PC, pyruvate carboxylase; PEPCK2, phosphoenolpyruvate carboxykinase 2; PGM, phosphoglycerate mutase; PGI, phosphoglucoisomerase; PGK, phosphoglycerate kinase; PPP, pentose phosphate pathway; TPI, triose phosphate isomerase. Gluconeogenesis pathway (purple), lactic carbon (green arrows), glutaminolytic carbon (blue arrows).