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. 2019 Nov 21;20:51. doi: 10.1186/s12860-019-0235-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Characterisation of CB-MSC senescence marker (p53, p21^waf1 and p16^INK4a) expression under normoglycaemic and hyperglycaemic conditions. a Significant differences in p53 gene expression were shown between PD15 and PD50, PD100 and PD200 under normoglycaemic and hyperglycaemic conditions. However, only CB-MSCs at PD100 demonstrated significant higher p53 expression in high glucose, compared to normal glucose conditions. b p21^waf1 exhibited very low expression, with no significant differences in expression between normoglycaemic and hyperglycaemic conditions. c p16^INK4A expression was low across all PDs, although CB-MSCs at PD15 under both normoglycaemic and hyperglycaemic conditions demonstrated highest p16^INK4A expression, which declined by PD50 onwards. Significance between CB-MSC populations are shown, **p < 0.01, *p < 0.05