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. 2019 Nov 21;10:344. doi: 10.1186/s13287-019-1458-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Linc-ADAMTS5, LncRNA-CIR, HOTTIP, TUG1, GAS5, and LncRNA-MSR inhibit the ECM degeneration through influencing the expression of ECM protease MMPs and ADAMTS. Upregulation of lncRNA DANCR and downregulation of PCGEM1 could promote the proliferation of stem cell to regulate the cartilage regeneration