Fig. 5.

Analgesic effects of ALM16 in acetic acid-induced writhing mice. Writhing number was measured per 10 and 15 min after a 0.8% acetic acid injection. a Injection of A, L and ALM16 (400 mg/kg b.w.) or celecoxib (100 mg/kg b.w.). b Injection of ALM16 only in a dose dependent manner. The results are expressed as the mean ± S.E.M. (n = 8). Data were analyzed by one-way ANOVA Tukey’s test to compare all of the tested groups. ^#p < 0.05, ^##p < 0.01 and ^*p < 0.05, ^**p < 0.01 compared with the control group at 10 and 15 min after acetic acid injection, respectively