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. 2019 Nov 21;7:322. doi: 10.1186/s40425-019-0808-5

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Proposed management strategy for hepatitis B surface antigen (HBsAg)-positive patients starting anti-PD-1-antibody-containing immunotherapy. (^*) The optimal duration of prophylactic antiviral therapy after the discontinuation of anti-PD-1 therapy remains to be determined. Anti-PD-1, anti-programmed cell death 1; PD-L1, programmed cell death-ligand 1; HBsAg, hepatitis B surface antigen; HBV, hepatitis B virus