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. 2019 Nov 21;7:322. doi: 10.1186/s40425-019-0808-5

Table 2.

Details of the 6 Patients with HBV reactivation

Patients Characteristics Baseline At reactivation
Patient Age (years) Gender Cancer type Anti-tumor therapy HBV DNA (IU/mL) Antiviral prophylaxis Weeks from start of immunotherapy HBV DNA (IU/mL) Peak ALT (U/L) Anti-PD-1/PD-L1 therapy disruption Antiviral treatment Time for achieving HBV-DNA undetectable (weeks) Time for ALT recovery (weeks)
1 48 M NPC Camrelizumab Undetectable Nil 3 7.81 × 103 191.4 Delayed Entecavir 1 2
2 47 M NPC Camrelizumab Undetectable Nil 16 6.98 × 104 203.0 Delayed Entecavir 4 4
3 39 M Melanoma Pembrolizumab Undetectable Nil 28 2.10 × 103 27.6 No Nil 5 NA
4 36 M HCC Nivolumab Undetectable Entecavir 12 1.80 × 103 298 Discontinued Entecavir plus tenofovir 1 3
5 45 M HNSCC Toripalimab Undetectable Nil 35 4.04 × 106 281.2 Delay Entecavir 3 6
6a 41 F Soft Tissue Sarcoma Nivolumab Undetectable Nil 20 6.00 × 107 465.1 NA Entecavir 8 4

aHBV reactivation in this patient occurred 6 weeks after immunotherapy was discontinued; other HBV reactivation occurred during anti-PD-1/PD-L1 thearpy

Abbreviations: M male, F female, HBV hepatitis B virus, NPC nasopharyngeal carcinoma, HCC hepatocellular carcinoma, HNSCC head and neck squamous cell cancer, ALT alanine aminotransferase, NA not applicable