Table 1.
Clinical variables in patients with high and low expression of PAR2
| Variable | PAR2 expression | P value | |
|---|---|---|---|
| Low expression | High expression | ||
| Sample size | 63 | 139 | |
| Age, years | 0.074 | ||
| > 50 | 25 (39.7%) | 74 (53.2%) | |
| ≤50 | 38 (60.3%) | 65 (46.8%) | |
| Gender | 0.187 | ||
| Male | 57 (90.5%) | 116 (83.5%) | |
| Female | 6 (9.5%) | 23 (16.5%) | |
| AFP, ng/mL | 0.067 | ||
| < 20 | 18 (28.6%) | 24 (17.3%) | |
| ≥ 20 | 45 (71.4%) | 115 (82.7%) | |
| Cirrhosis | 0.889 | ||
| Yes | 53 (84.1%) | 118 (84.9%) | |
| No | 10 (15.9%) | 21 (15.1%) | |
| Tumor size, cm | 0.154 | ||
| < 5 | 23 (36.5%) | 37 (26.6%) | |
| ≥ 5 | 40 (63.5%) | 102 (73.4%) | |
| Differentiation | < 0.001 | ||
| Well-moderate | 22 (34.9%) | 12 (8.6%) | |
| Poor-undifferentiated | 41 (65.1%) | 127 (91.4%) | |
| TNM stage | 0.015 | ||
| I–II | 42 (66.7%) | 67 (48.2%) | |
| III–IV | 21 (33.3%) | 72 (51.8%) | |
| Vascular invasion | 0.290 | ||
| Yes | 8 (12.7%) | 26 (18.7%) | |
| No | 55 (87.3%) | 113 (81.3%) | |
Abbreviations: PAR2 proteinase activated receptor 2, AFP alpha-fetoprotein