Table 2.

Univariate and multivariate analyses of variables for overall survival

Variables	Univariate analysis				Multivariate analysis
	HR	95% CI	P		HR	95% CI	P
Age	0.918	0.668–1.262	0.598
Sex	0.739	0.459–1.191	0.215
AFP	1.121	0.788–1.594	0.525
Cirrhosis	1.184	0.804–1.743	0.393
Tumor size, cm	1.100	0.786–1.538	0.579
Differentiation	0.824	0.518–1.312	0.415
TNM stage	1.094	1.002–1.709	0.017
Vascular invasion	2.642	1.751–3.985	< 0.001		2.118	1.648–3.845	< 0.001
PAR2 expression	1.427	1.062–2.118	0.027		1.347	1.041–1.914	0.032

Abbreviations: PAR2 proteinase activated receptor 2, AFP alpha-fetoprotein