Table 3.

Lung stress and heterogeneity parameters

	PEEP 5 cmH2O			PEEP 15 cmH2O			p value
	Inspiratory flow			Inspiratory flow			Flow	PEEP	Interaction
	Low	Medium	High	Low	Medium	High
PL at P1, cmH2O	2 [0–4]	2 [1–3]	2 [1–4]	9† [6–11]	8† [7–11]	10 [9–12]	0.004	<0.001	0.209
PL at Pplat, cmH2O	1 [0–2]	1 [0–2]	0 [−1–1]	6 [5–9]	8 [5–9]	9 [6–10]	0.304	<0.001	0.219
PL at PEEPtot, cmH2O	−5 [−8–−3]	−5 [−7–−3]	−6 [−8–−3]	1 [1–2]	2 [1–2]	2 [1–3]	0.944	<0.001	0.011
ΔPL at P1, cmH2O	7 [5–9]	7 [6–9]	9 [7–11]	6† [4–9]	7 [6–8]	9 [6–10]	0.010	0.697	0.767
ΔPL at Pplat, cmH2O	6 [4–7]	6 [5–7]	6 [5–9]	6 [3–7]	6 [5–6]	6 [5–6]	0.250	0.637	0.906
Vtndep/Vtdep	1.69 [1.60–2.61]	1.72 [1.63–2.86]	1.73 [1.61–2.79]	1.37*,† [1.20–1.47]	1.42 [1.23–1.56]	1.41 [1.23–1.54]	0.002	0.003	0.267
GI	82† [67–88]	85 [68–91]	85 [68–92]	61 [58–66]	59 [58–67]	59 [57–67]	0.050	<0.001	0.148

PL absolute transpulmonary pressure, P1 end-inspiratory airway pressure at 0 flow, Pplat end-inspiratory plateau airway pressure, Pplat end-inspiratory plateau airway pressure, PEEPtot total (set + intrinsic) positive end-expiratory pressure, ΔP_L delta transpulmonary pressure, GI global inhomogeneity index

*p < 0.05 vs medium inspiratory flow; †p < 0.05 vs high inspiratory flow