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. 2019 Nov 15;10:746. doi: 10.3389/fendo.2019.00746

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Copyright © 2019 DiStefano and Jonklaas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Studies assessed as including patients with high residual thyroid function (>20%) and/or T3 levels predicted by simulation, grouped according to whether improved outcomes, preference, both improved outcomes and preference, or neither improved outcomes nor preference was reported. Red font indicates high simulated T3 levels. Blue font indicates medium simulated T3 levels. Green font indicates low simulated T3 levels. Underlined indicates correctly predicted. Italics indicate incorrect prediction. Bunevicius is 2002 study. (B) Studies assessed as including patients with medium residual thyroid function (10-20%) and/or T3 levels predicted by simulation, grouped according to whether improved outcomes, preference, both improved outcomes and preference, or neither improved outcomes nor preference was reported. Red font indicates high simulated T3 levels. Blue font indicates medium simulated T3 levels. Underlined indicates correctly predicted. (C) Studies assessed as including patients with low residual thyroid function (<10%) and/or T3 levels predicted by simulation, grouped according to whether improved outcomes, preference, both improved outcomes and preference, or neither improved outcomes nor preference was reported. Red font indicates high simulated T3 levels. Blue font indicates medium simulated T3 levels. Green font indicates low simulated T3 levels. Underlined indicates correctly predicted. Bunevicius is 1999 study.