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. 2019 Nov 15;7:320. doi: 10.3389/fbioe.2019.00320

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Copyright © 2019 Yang, Wang, Wan, Gu and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Photoluminescence excitation (black solid line) and emission (black dotted line) spectra of Cr³⁺ doped n-ZGO. (B) Schematic representation of in vivo imaging after in situ activation of persistent luminescence nanoparticles (PLNPs). (C) Optical image of a tumor-bearing mouse. (D) Persistent luminescence image of a tumor-bearing mouse 2 h after injection of ZGO-PEG NPs. (E) Persistent luminescence image of a tumor-bearing mouse immediately after LED illumination, 4 h after injection of ZGO-PEG NPs.