Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Nov 15;7:320. doi: 10.3389/fbioe.2019.00320

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Yang, Wang, Wan, Gu and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

(A) Schematic illustration for the preparation of charge-convertible CD-based drug nanocarrier. pHe means tumor extracellular pH. (B) Schematic illustration for the drug delivery process: (1) negative charge/PEGylation to prolong circulation time, (2) accumulation at the tumor site through the EPR effect, (3) responsiveness to tumor extracellular pH, (4) effective uptake by cancer cells, (5) facilitated endosome escape by the “proton sponge” effect and controlled cisplatin release, and (6) cisplatin binding with DNA to exhibit cytotoxicity. (C) Relative tumor volume achieved from mice after intravenous treatments with CD-based drug nanocarrier. (D) Photographs of mice and excised tumors from representative euthanized mice. (E) H&E stained tumor slices from different groups after 14-day treatment. ^***P < 0.001.