TABLE 2.

Changes in RBC deformability, adhesivity, and export of the vasoactive mediators ATP and S-nitrosothiols in sickle cell disease, RBC storage or transfusion, and sepsis.

	Disease or condition
	Sickle cell disease	RBC transfusion/RBC storage lesion	Sepsis
RBC function
RBC deformability	↓, especially when sickled (Alapan et al., 2014; Huisjes et al., 2018)	↓ progressive over weeks (Bennett-Guerrero et al., 2007; Barshtein et al., 2016)	↓ (Powell et al., 1993; Baskurt et al., 1998)
ATP content ATP export	↓ (Sabina et al., 2009) ↓ (unpublished observations, TJM and M. Telen)	↓ (both) progressive over weeks (Valeri and Hirsch, 1969; Zhu et al., 2011)	↓ (Bateman et al., 2015; Lopez Domowicz et al., 2019) ↓ (Bateman et al., 2015; Lopez Domowicz et al., 2019)
SNO content	↓ (Pawloski et al., 2005)	↓ within hours (Bennett-Guerrero et al., 2007; Reynolds et al., 2007)	↑ (Jourd’heuil et al., 2000; Crawford et al., 2004; Liu et al., 2004; Doctor et al., 2005)
SNO export or vasoactivity	↓ (Pawloski et al., 2005)	↓ within hours (Bennett-Guerrero et al., 2007; Reynolds et al., 2007)	↑ (Crawford et al., 2004)
RBC adhesivity	↑ (Hebbel, 1997; Zennadi et al., 2004)	↑ (Anniss and Sparrow, 2007; Zhu et al., 2011)	↑ by LPS (Eichelbrönner et al., 2003)