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. 2019 Nov 15;10:1215. doi: 10.3389/fneur.2019.01215

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Copyright © 2019 Jing, Yang, Fu, Wang, Yang, Yuan, Chen, Ding, Chen and Tian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Serpina3k alleviated the loss and apoptosis of neurons at 7 days after TBI. (A) Representative images of TUNEL- and NeuN-positive cells in peri-contusion areas of brain tissue from mice in the sham, TBI+vehicle, and TBI+A3k groups. White arrows show normal neurons, white triangles demonstrate apoptotic neurons. Scale bar = 10 μm. Quantification of normal neurons (B) and apoptotic neurons (C). Data represent the mean ± SD (n = 5 per group). *P <0.05, **P <0.01, TBI+A3K group vs. TBI+vehicle group.