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. 2019 Nov 15;10:1215. doi: 10.3389/fneur.2019.01215

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Copyright © 2019 Jing, Yang, Fu, Wang, Yang, Yuan, Chen, Ding, Chen and Tian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Serpina3k regulated MAPK and mitochondrial apoptosis pathways after experimental SI in SH-SY5Y cells. Representative western blots of p-ERK and ERK (A), p-P38 and P38 (C), Bax and Bcl-2 (E), and cleaved caspase-3 and caspase-3 (G). Quantified bar graphs of p-ERK/ERK (B), p-P38/P38 (D), Bax/Bcl-2 (F), and cleaved caspase-3/caspase-3 (H) ratios at 2 h after SI in the control, SI+vehicle, and SI+A3K groups. β-tubulin, GAPDH, and β-actin were used as loading and internal controls. Data represent the mean ± SD (n = 5 per group). *P <0.05, **P <0.01, SI+A3K vs. SI+vehicle group.