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. 2019 Nov 15;9:1189. doi: 10.3389/fonc.2019.01189

Figure 5.

Figure 5

Silencing MUS81 and RAD51 contributes to a dysfunctional DNA repair system. (A) The formation of RAD51 foci was inhibited in MUS81 knockdown cells (SKOV3). MUS-KD cells were unable to elicit RAD51 foci in the presence of UV exposure after 24 h, representative images show in (I); Data represent mean ± SD from three independent experiments (II), *P < 0.05, **P < 0.01. (B) The levels of RAD51 and MUS81 expression in SKOV3 cell were upregulated significantly after treatment with CPT 4 h. (C) MUS81 knockdown increased the sensitivity of SKOV3 cells to CPT. *P < 0.05. (D) A schematic diagram of the proposed molecular model of MUS81 intermediates dysfunctional DNA repair systems and drug sensitivity. The dysfunctional DNA repair system or impaired HR pathway by MUS81 inhibition could enhance the effect of therapeutic drugs (CPT/Olaparib) on SOC cells.