TABLE 1.

Summary statistics for the proteomic study.

	Detected proteins (n)	Upregulated (n)	Present in TG, low/absent in WT	Downregulated (n)	Low/absent in TG, present in WT	DYRK1A interactors	DYRK1A interactors (in direct interactors)
TG.NT-WT.NT	2685	33	18	24	23	Hras	Braf, Dnm1, Psen1, Efnb1, Efnb2, Grb2, Rbl2, Sirt1
WT.greentea-WT.NT	2695	43	18	37	17	Capn1, Eif4e, Hras, Tsc1, Tollip	Braf, Grin2a, Dnm1, Stat3, Psen1, Efnb1, Efnb2, Grb2, Eif4ebp1, Amph
WT.EE-WT.NT	2758	28	34	19	43	Hras, Rbm39, Nup155, Tollip, Myo1c	Braf, Stat3, Efnb1, Efnb2, Ywhaq, Sh3gl2, Sirt1
WT.greentea + EE-WT.NT	2690	38	22	34	16	Cnbp, Hras, Huwe1, Pgam5, Ablim1	Braf, Stat3, Brca1, Eif4e, Rest, Sirt1, Rai14
TG.greentea-TG.NT	2650	23	12	40	23	Lrch1, Fntb, Spred1	Dnm1, Stat3, Psen1, Efnb1, Efnb2, Epha2, Btrc, Grb2, Rbm39
TG.EE-TG.NT	2680	35	27	32	19	Ech1, Spred1, Tsc1	App, Dnm1, Psen1, Efnb1, Efnb2, Bicd2, Hipk2
TG.greentea + EE-TG.NT	2756	37	46	65	56	Cdkn1b, G6pdx, Srsf7, Tsc1	Ccnd1, Psen1, Nfatc2, E4f1, Hipk2
Rescued by the green tea extract	33	17	3	7	6		Dnm1, Psen1, Efnb1, Efnb2, Grb2
Rescued by EE	34	13	4	8	9	Hras	Braf, Dnm1, Psen1, Efnb1, Efnb2, Rbl2
Rescued by the combined treatment	46	15	7	12	12		Psen1

Proteins were considered differentially expressed if having an adjusted p-value lower than 0.05 and a log₂ (fold change) greater than 0.3 or lower than -0.3. Further details are provided in Supplementary Tables S1–S10.