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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Respir Physiol Neurobiol. 2019 Sep 7;271:103289. doi: 10.1016/j.resp.2019.103289

Figure 7.

Figure 7.

Maximum diaphragm specific force is presented as a function of time for CLP (red) and CLP + taurine treated animals (blue). The CLP + taurine group was treated with taurine, 75 mg/kg/d until sacrifice. Subgroups of animals were sacrificed at 24 hours, 48 hours, and 72 hours after sham or CLP surgeries. Saline treated animals sacrificed immediately after injections served to provide time zero control measurements. CLP treated animals had large reductions in diaphragm specific force generation by 24 hours and these reductions in force persisted at 48 hours and 72 hours after study inclusion. Taurine treatment ablated CLP induced reductions in muscle force generation, with force for the CLP + taurine group remaining the same as the control, non-septic group at 24 hours, 48 hours and 72 hours after study inclusion (p<0.01 for comparison of the two groups at each time point).