Table 1.
A brief summary of changes in immune factors following CCI and BIRT377 treatment
| Tissue Regions | Immune Parameters | Male | Female | ||
|---|---|---|---|---|---|
| CCI# | CCI+ BIRT377## | CCI# | CCI+ BIRT377## | ||
| Sciatic Nerve (Ipsilateral) | CCL2 | Up | Down | Up* | |
| IL-1β | Up | Down | Up* | Down | |
| TNF | Up | Down | Up | Down | |
| IL-10 | Up | Up* | Up | ||
| TGFβ−1 | Up | Up* | Up | ||
| CD11b | Up | Down | Up* | ||
| CD3 | Up | Down | Up | ||
| FOXP3 | Up | Up | Up | ||
| IL-17A | Up | Up* | Down | ||
| DRGs (Ipsilateral) | CCL2 | Up | Up | ||
| IL-1β | Up | Down | Up* | Down | |
| TNF | Up | Down | Up | ||
| IL-10 | Up | Up | |||
| FOXP3 | Up | ||||
| Lumbar Spinal Cord (Ipsilateral) | CCL2 | Up | Up* | Down | |
| IL-1β | Up | ||||
| TGFβ−1 | Up | Up | |||
| IL-10 | Down | Up | Down | Up | |
| FOXP3 | Up* | Down | |||
| IL-17A | Up* | Down | |||
| GFAP | Up | Down | Up | ||
| TMEM119 | Up | Up | |||
| Lumbar spinal Cord (Contralateral) | CCL2 | Down | |||
| IL-1β | |||||
| TGFβ−1 | |||||
| IL-10 | Up | Down | |||
| FOXP3 | |||||
| GFAP | Up | Down | Up* | Down | |
| TMEM119 | Up | Up | |||
*
Fold changes were significantly different in males versus females.
#
Comparison between Sham+Veh and CCI+Veh,
##
comparison between CCI+Veh and CCI+BIRT377