FIG 5.

Higher diversity indicates higher clonality in normal tissues and solid tumors. (A) Additional available data from Zheng et al²¹ for CD34⁺ cells, CD4⁺ helper T cells, CD14⁺ monocytes, and CD19⁺ B cells were run through pipeline S (Data Supplement), and the continuum of diversity was calculated for each population. The naturally polyclonal population (CD34⁺) shows the highest diversity score. Each of the other differentiated immune cell compartments are more homogeneous across orders of diversity. (B) In solid tumors, location matters. Normal tumor matched lung carcinoma samples were obtained from publicly available data for six patients with lung cancer²² (individual patients; Data Supplement). The diversity metric across q demonstrates an increase in diversity within tumors across different tumor locations.