Fig 3.

Measurable and nonmeasurable disease. (A and B) If there is no measurable disease, then no tumor imaging biomarker can be extracted. (C) If a lesion is measurable according to Response Evaluation Criteria in Solid Tumors (RECIST) 1.1, radiologists can segment the tumor. (D and E) The three different colors show the contours delineated by three different radiologists in three dimensions (volume rendering) by using the semi-automated segmentation described in the Patients and Methods section.