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. 2019 Nov 21;14(11):e0222399. doi: 10.1371/journal.pone.0222399

Table 5. Hierarchical regression predicting head circumference for gestational age (Z-score; N Final model = 888).

Block 1 Block 2 Block 3 Block 4
Variables Coefficient 95% CI LL 95% CI UL Coefficient 95% CI LL 95% CI UL Coefficient 95% CI LL 95% CI UL Coefficient 95% CI LL 95% CI UL
Demographics
Clinic                        
Mbekweni - - - - - - - - - - - -
TC Newman -0.247* -0.460 -0.034 -0.271* -0.516 -0.026 -0.195 -0.452 0.062 -0.060 -0.345 0.225
Maternal age 0.032** 0.013 0.050 0.030** 0.009 0.051 0.036** 0.015 0.057 0.022 -0.001 0.046
Married or cohabitating 0.028 -0.185 0.240 0.050 -0.173 0.273 0.058 -0.167 0.283 -0.021 -0.253 0.210
SES
Low - - - - - - - - - - - -
Low-moderate -0.233 -0.505 0.040 -0.175 -0.457 0.108 -0.173 -0.457 0.110 -0.151 -0.438 0.135
Moderate-high -0.307* -0.582 -0.032 -0.311* -0.596 -0.025 -0.293* -0.582 -0.004 -0.270 -0.564 0.024
High -0.040 -0.329 0.248 -0.055 -0.357 0.247 -0.101 -0.405 0.204 -0.107 -0.421 0.207
Food Insecure -0.088 -0.305 0.130 -0.004 -0.234 0.226 0.030 -0.206 0.266 0.024 -0.215 0.262
Pregnancy and Physical Health
BMI at Enrollment 0.003 -0.014 0.021 -0.003 -0.021 0.015 -0.009 -0.028 0.009
Pregnancy Complications
Hypertension 0.235 -0.309 0.778 0.320 -0.227 0.867 0.270 -0.298 0.838
(Pre)-eclampsia 0.059 -0.612 0.731 0.031 -0.636 0.698 0.068 -0.602 0.738
Anaemia 0.085 -0.160 0.331 0.070 -0.178 0.318 0.042 -0.205 0.290
Gestational diabetes 1.107 -0.007 2.221 1.348* 0.168 2.527 1.386* 0.211 2.560
Asthma - - - - - - - - -
HIV Infected -0.056 -0.335 0.222 0.002 -0.281 0.285 0.016 -0.269 0.302
Mental Health and Psychosocial Factors
Depressive Symptoms (EPDS score) -0.017 -0.040 0.007 -0.013 -0.036 0.010
Psychological Distress (SRQ-20) -0.027 -0.059 0.005 -0.028 -0.060 0.004
IPV during pregnancy   -0.048 -0.276 0.181 -0.029 -0.260 0.201
Substance Use During Pregnancy & Primigravida
Alcohol use (moderate-high risk)   -0.440* -0.779 -0.101
Cotinine level
Non-smoker - - -
Passive 0.176 -0.093 0.444
Active -0.193 -0.515 0.130
Primigravida                   -0.376** -0.649 -0.103
R2 p-value R2 p-value R2 p-value R2 p-value
0.029 <0.001 0.037 0.001 0.054 <0.001 0.077 <0.001
Change R2 p-value Change R2 p-value Change R2 p-value
          0.009 0.351 0.016 0.004 0.023 <0.001

*p<0.05

**p<0.01

***p<0.001; 95% CI LL = 95% Confidence Interval Lower Limit, 95% CI UL = 95% Confidence Interval Upper Limit